Michael S. Brown

Explore the timeline of Michael S. Brown, an esteemed American physician and geneticist. Delve into the key milestones and achievements throughout his illustrious career, from his groundbreaking research in cholesterol metabolism to winning the Nobel Prize in Physiology or Medicine in 1985.

Born: April 13, 1941
Geneticist
University of Pennsylvania

13 april 1941

1 juni 1966

1 januari 1973

14 oktober 1985

10 november 1988

1 januari 1993

30 april 1997

1 januari 2003

1 januari 2005

1 januari 2021

13april
1941
13 April 1941

Birth of Michael S. Brown

Michael Stuart Brown was born on April 13, 1941, in Brooklyn, New York City, USA. He later became a renowned geneticist known for his work on cholesterol metabolism. His early life in Brooklyn set the stage for his academic pursuits in medicine and genetics, leading him to become a leading figure in the field of biochemical research.

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01juni
1966
01 June 1966

Graduation from University of Pennsylvania

In June 1966, Michael S. Brown graduated from the University of Pennsylvania School of Medicine with an M.D. degree. This marked a significant step in his journey towards becoming a leading medical researcher. His medical education provided the foundation for his future contributions to the understanding of cholesterol and genetics.

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01januari
1973
01 January 1973

Research on Familial Hypercholesterolemia

In 1973, Michael S. Brown and Joseph L. Goldstein began their groundbreaking research on familial hypercholesterolemia, a genetic disorder characterized by high cholesterol levels. Their collaboration ultimately led to the identification of the LDL receptor and provided insights into the regulation of cholesterol metabolism, revolutionizing treatment approaches.

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14oktober
1985
14 October 1985

Nobel Prize in Physiology or Medicine

On October 14, 1985, Michael S. Brown, along with Joseph L. Goldstein, was awarded the Nobel Prize in Physiology or Medicine for their discoveries concerning the regulation of cholesterol metabolism. Their work uncovered the underlying mechanisms of cholesterol regulation, leading to the development of statin drugs, which have since saved millions of lives worldwide.

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10november
1988
10 November 1988

National Medal of Science Award

In November 1988, Michael S. Brown and Joseph L. Goldstein were awarded the National Medal of Science for their contributions to our understanding of heart disease. The National Medal of Science is the United States' highest scientific honor, recognizing individuals who have made outstanding contributions to the knowledge and understanding of the world.

01januari
1993
01 January 1993

Discovery of Sterol Regulatory Element-Binding Proteins

In 1993, Michael S. Brown and Joseph L. Goldstein discovered sterol regulatory element-binding proteins (SREBPs), a family of transcription factors that play a critical role in lipid metabolism. This discovery expanded the understanding of how cells regulate cholesterol and fatty acids, contributing to the development of new therapeutic approaches for metabolic diseases.

30april
1997
30 April 1997

Elected to the American Philosophical Society

On April 30, 1997, Michael S. Brown was elected to the American Philosophical Society, an esteemed organization that honors those who have made extraordinary contributions to science, letters, and the arts. This honor reflects Brown's status as a leading scientist and his groundbreaking work in the field of biochemistry and genetics.

01januari
2003
01 January 2003

Discovery of Insig Proteins

In 2003, Michael S. Brown and Joseph L. Goldstein discovered Insig proteins, which are key regulators of cholesterol homeostasis in mammalian cells. This discovery further elucidated the complex pathways involved in cholesterol metabolism, highlighting the intricate regulatory mechanisms controlling cellular lipid levels.

01januari
2005
01 January 2005

Lasker Award in Basic Medical Research

Michael S. Brown and Joseph L. Goldstein were awarded the Lasker Award in Basic Medical Research in 2005 for their discoveries that helped to fill in key pieces of the cholesterol regulation puzzle. The Lasker Awards are among the most prestigious in medical science, often considered a precursor to the Nobel Prize.

01januari
2021
01 January 2021

Continuing Influence in Scientific Research

As of 2021, Michael S. Brown continues to be a major influence in the field of biomedical research. His ongoing contributions to the scientific community and mentorship of young scientists highlight his enduring impact on medical science. He remains a prominent figure, contributing to advancements in understanding cholesterol and lipid metabolism.

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