Fraser Stoddart

Fraser Stoddart's group introduced the concept of 'mechanical bonds', a groundbreaking development in the field of chemistry where molecules are linked not by traditional covalent bonds but through mechanical interlocking. This work laid the foundation for the development of molecular machines, an area that would earn him the Nobel Prize later. This innovation opened new possibilities in the design of molecules that can perform specific tasks or mimic machine-like functions.

Stoddart's substantial contributions to the development of rotaxanes, molecules consisting of a macrocycle threaded onto a molecular axle, advanced the study of molecular machines. His research demonstrated how the mechanical bonds in rotaxanes can facilitate controlled motion at the molecular level, which is fundamental to constructing molecular machines. Rotaxanes are now a core component of nanotechnology and molecular electronic circuits.

In 2001, Stoddart's pioneering work in nanoelectromechanical systems (NEMS) using rotaxanes transformed the approach to constructing tiny, efficient machines. His research demonstrated how these systems could achieve switch-like behavior at the nanoscale, leveraging the unique properties of mechanically interlocked molecules. This work was pivotal in the development of nanoscale devices and the emerging field of nanotechnology.

Fraser Stoddart joined Northwestern University as a Board of Trustees Professor of Chemistry in 2007, bringing his expertise in supramolecular chemistry and molecular nanotechnology. At Northwestern, Stoddart continued his groundbreaking research into molecular machines and nanotechnology, fostering valuable collaborations and contributing significantly to the university's reputation as a leader in chemical research.

Fraser Stoddart was awarded the Nobel Prize in Chemistry in 2016, along with Jean-Pierre Sauvage and Bernard L. Feringa, for their design and synthesis of molecular machines. Stoddart's pioneering work on the development of rotaxanes and catenanes, which operate as molecular shuttles, switches, and machines, was crucial in pushing the boundaries of what can be achieved by chemistry at a molecular level.

In 2017, Fraser Stoddart and his team developed an artificial molecular pump, which mimics the process of active transport used by living cells. This artificial pump is capable of sustaining chemical energy to drive molecules from a low-energy state to a high-energy state. The development of this pump marks a significant advancement in molecular machinery and has potential applications in drug delivery and molecular transport systems.

Under Fraser Stoddart's leadership, an exceptional international collaboration was established in 2019 between universities and research institutions across continents. This collaboration facilitated significant advancements in the field of organic and supramolecular chemistry, driven by shared resources and knowledge. Such initiatives highlight the importance of collaborative efforts in achieving scientific breakthroughs and addressing global challenges.

In late 2020, Fraser Stoddart's groundbreaking research provided new insights into the application of molecular electronics, where electronic functions are built not from silicon but from organic molecules. His work showed how integrating rotaxane-based structures can lead to the development of advanced molecular diodes and circuits, showing promise for more sustainable and efficient electronic devices.

Fraser Stoddart's announcement in early 2021 regarding a new mechanism of molecular pumping was a triumph in supramolecular chemistry. His research unveiled a sophisticated mechanism by which these pumps operate, adding depth to the understanding of molecular propulsion systems. This work is pivotal for the advancement of next-generation transport and delivery systems in medical and industrial applications.

In 2022, Fraser Stoddart was honored with the prestigious Paracelsus Prize by the Swiss Chemical Society for his outstanding contributions to the field of chemistry, particularly in molecular machines and supramolecular chemistry. This prize highlights Stoddart's achievements in advancing scientific knowledge and his role in fostering international scientific cooperation and innovation.