Edwin G. Krebs

Edwin G. Krebs passed away on December 21, 2009, in Seattle, Washington, at the age of 91. His contributions to biochemistry, particularly the discovery of reversible protein phosphorylation, have left a lasting impact on scientific research. He is remembered as a pioneering scientist and a revered figure in the scientific community.

In June 2001, Edwin G. Krebs published an autobiography recounting his journey through scientific endeavours and personal experiences. This work provided insights into his early life, scientific curiosity, and the process leading to his groundbreaking research. The autobiography is a reflective piece that offers a comprehensive view of his life and career.

On December 10, 1992, Edwin G. Krebs, along with Edmond H. Fischer, was awarded the Nobel Prize in Physiology or Medicine for their discoveries concerning reversible protein phosphorylation. Their work unveiled the regulatory role of reversible protein phosphorylation and its significance in cells, providing a universal mechanism for biochemical regulation. This recognition was one of the most prestigious acknowledgments of their scientific contributions.

Edwin G. Krebs retired from the active faculty at the University of Washington in 1988. After retirement, he continued to contribute to the scientific community through advisory roles and remained an influential figure in scientific circles. His career left a lasting legacy on the field of biochemistry and pharmacology.

In 1968, Edwin G. Krebs accepted a position as Chair of the Department of Pharmacology at the University of Washington School of Medicine. Under his leadership, the department grew in prominence and contributed significantly to the fields of pharmacology and biochemistry. His role as chair reflected his influence and reputation in the scientific community.

In 1953, Edwin G. Krebs, along with Edmond H. Fischer, discovered reversible protein phosphorylation. This groundbreaking discovery showed that the addition of a phosphate group to a protein can regulate its function, which is a fundamental mechanism for cellular processes. This work had a profound impact on biochemistry and cell biology, shaping the future of molecular biology research.

Edwin G. Krebs graduated from Washington University School of Medicine in St. Louis with an M.D. degree on January 15, 1943. During his time there, he was attracted to basic research, which steered him toward a career that combined medical training with a passion for biochemical research. This educational achievement was a pivotal point in his career.

In September 1936, Edwin G. Krebs enrolled at the University of Illinois at Urbana-Champaign. He was initially interested in chemistry, influenced by his high school experiences, and later shifted his focus to biochemistry. This period laid the foundation for his future career in science and research, leading him to pursue advanced studies.

Edwin Gerhard Krebs was born on June 6, 1918, in Lansing, Iowa, USA. He was one of the four children of William Carl Krebs and Louise Helen Stegeman. His early years were influenced by the financial struggles of the Great Depression, and he developed a strong work ethic during his formative years. His father was a Presbyterian minister which also influenced his upbringing.