In 2022, Talitha Muusse played a significant role in the launch of 'Omroep Zwart', a new Dutch broadcaster aimed at promoting diversity and inclusion in media. Her involvement underscored her commitment to creating platforms that reflect a wide range of voices and perspectives in Dutch society.

In April 2021, Talitha Muusse announced her departure from 'Op1'. Her decision was influenced by a desire to focus more on her advocacy work and to explore new opportunities in journalism and public speaking. Her tenure at 'Op1' was noted for her engaging presentation style and commitment to social issues.

In 2020, Talitha Muusse joined the Dutch talk show 'Op1' as a presenter. Her role involved moderating discussions on current affairs, with a particular emphasis on youth issues and sustainability. Her presence on the show was marked by her dynamic interviewing style and ability to engage with diverse topics.

In 2018, Talitha Muusse began writing columns for NRC, where she focused on topics related to sustainability, youth engagement, and social innovation. Her columns were well-received for their insightful analysis and fresh perspectives on contemporary issues.

In 2015, Talitha Muusse co-founded Energieboot, a platform aimed at connecting young professionals with the energy transition sector. This initiative was part of her broader commitment to sustainability and engaging young people in impactful societal changes.