On October 23, 2022, Florian Lejeune showcased his scoring prowess by netting two goals for Rayo Vallecano in their La Liga match. This performance was a testament to his versatility and ability to contribute offensively, even as a central defender. His goals were crucial in securing a vital win for his team.

In July 2021, after a successful loan spell, Florian Lejeune signed a permanent deal with Deportivo Alavés. His performances during the loan were impressive enough to convince the Spanish club to retain him. This transfer marked a new chapter in Lejeune's career as he continued to ply his trade in La Liga, showcasing his talent and experience.

On September 22, 2020, Florian Lejeune was loaned to La Liga side Deportivo Alavés for the duration of the 2020-2021 season. The move was seen as an opportunity for Lejeune to gain regular playing time after recovering from his injuries. At Alavés, he became a regular starter, showcasing his defensive skills in one of Europe's top leagues.

In one of the most dramatic comebacks of the 2018-2019 Premier League season, Florian Lejeune scored two goals in stoppage time to help Newcastle United rescue a point in a 2-2 draw against Everton on April 6, 2019. This extraordinary feat further cemented his reputation as a defender capable of making significant contributions at both ends of the pitch.

In July 2018, Florian Lejeune suffered a serious cruciate knee ligament injury during a pre-season friendly. The injury was a significant setback as it ruled him out for the majority of the 2018-2019 Premier League season. Known for his resilience, Lejeune worked diligently on his rehabilitation to make a successful return to the squad.

On July 4, 2017, French defender Florian Lejeune completed a transfer from Eibar to Newcastle United for a reported fee of £8.7 million. Lejeune, known for his aerial ability and composure on the ball, quickly established himself as a key player in the heart of Newcastle's defense. His signing was part of Rafa Benítez's efforts to strengthen the squad following their promotion to the Premier League.